Tuesday, April 30, 2013

Tebow time over in NY

Desmond Trufant, Mike SmithAP

Versatility will be an important trait for players to have in the Bills defense.

An examination of T Bryant McKinnie?s visit with the Dolphins.

A look at the Patriots roster organized by contract length.

Former Jets special teams coach Mike Westhoff will be working on radio broadcasts of the team?s games.

What is FB Vonta Leach?s future with the Ravens?

The draft turned up plenty of options for Bengals QB Andy Dalton.

WR Davone Bess said it was ?bittersweet? when he first learned of his trade to the Browns.

The Steelers may be looking at WR Markus Wheaton?s speed as a replacement for what they lost when Mike Wallace signed in Miami.

Breaking down the Texans draft pick-by-pick.

LB Kelvin Sheppard gives the Colts some depth behind the rehabbing Pat Angerer.

The Jaguars waived wide receiver Jerrell Jackson and defensive tackle Jerome Long to get to the 90-man limit.

Titans QB Jake Locker likes the pick of G Chance Warmack, who he calls ?a downhill player who brings an attitude.?

LB Shaun Phillips? versatility was part of his appeal to the Broncos.

Chiefs G.M. John Dorsey feels ?really good? about the state of his team right now.

Peter Schraeger of FOXSports.com likes what the Raiders have done this offseason.

LB Manti Te?o will wear No. 50 for the Chargers.

Nick Mangold?s name came up when Cowboys offensive line coach Bill Callahan spoke to new C Travis Frederick.

Former NFL G.M. Bill Polian likes that the Giants picked QB Ryan Nassib.

Eagles coach Chip Kelly will be happy to have TE Zach Ertz working for him instead of against him this season.

Running down the draft hits and misses for the Redskins.

DT Zach Minter hopes to go from undrafted to the Bears roster.

The Lions took some risks during the draft.

Five Packers offseason practices will be open to the public.

The Vikings didn?t fill every hole during the draft.

New Falcons CB Desmond Trufant will be wearing the same number as former Falcons CB Deion Sanders.

How will Panthers QB Cam Newton?s foray into fashion work out?

LB Chase Thomas is focused on making the Saints instead of the fact that he was undrafted.

An explanation of why the Buccaneers should steer clear of QB Tim Tebow.

Cardinals WR Dan Buckner didn?t have to travel far from the University of Arizona to latch on as an undrafted free agent.

It looks like the Rams are ready to get more aggressive offensively.

49ers coach Jim Harbaugh referenced Mike Ditka when discussing rookie TE Vance McDonald and then gave McDonald uniform No. 89, Ditka?s old digits.

Which Seahawks draft pick is going to make the biggest impact?

Source: http://profootballtalk.nbcsports.com/2013/04/29/rex-on-tebow-things-did-not-work-out-the-way-we-all-had-hoped/related/

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President calls gay basketball player and offers support

WASHINGTON (AP) ? A groundbreaking pronouncement from NBA veteran Jason Collins ? "I'm gay" ? reverberated Monday through Washington, generating accolades from lawmakers on Twitter and a supportive phone call from President Barack Obama.

Hours after Collins disclosed his sexuality in an online article, Obama reached out by phone, expressing his support and telling Collins he was impressed by his courage, the White House said.

Collins, 34, becomes the first active player in one of four major U.S. professional sports leagues to come out as gay. He has played for six teams in 12 seasons, including this past season with the Washington Wizards, and is now a free agent.

Collins' declaration in a first-person account posted on Sports Illustrated's website garnered particular attention from Democrats, many of whom have recently announced their support for gay marriage despite opposing it in the past. Obama announced his support last year during his re-election campaign.

Organizing for Action, a grassroots group run by Obama loyalists that grew out of his 2012 re-election campaign, offered its support for Collins as well, writing to Collins on Twitter on Monday that the group's supporters "stand with you today."

And first lady Michelle Obama chimed in on Twitter on Monday afternoon to applaud Collins.

"So proud of you, Jason Collins! This is a huge step forward for our country. We've got your back!" the tweet read. It was signed "mo" ? signifying that the first lady personally wrote the message.

Former President Bill Clinton also voiced encouragement, releasing a statement that asks fans, NBA colleagues and the media to support and respect him. Clinton said he has known Collins since he attended Stanford University with his daughter Chelsea.

Clinton said Collins' announcement Monday is an "important moment" for professional sports and the history of the lesbian, gay, bisexual and transgender community.

Collins is "a good man who wants no more than what so many of us seek ? to be able to be who we are, to do our work, to build families and to contribute to our communities," Clinton said. "For so many members of the LGBT community, these simple goals remain elusive."

Chelsea Clinton also tweeted her support for Collins Monday, saying she was proud of her friend for having the strength and courage to be the first openly gay player in the NBA..

Earlier Monday, White House spokesman Jay Carney said Collins' decision was another example of progress and evolution in the U.S. as Americans grow more accepting of gay rights and same-sex marriage. He said he hoped the 34-year-old center's NBA colleagues will also offer support.

"We view that as another example of the progress that has been made and the evolution that has been taking place in this country," Carney said.

Chad Griffin, the president of Human Rights Campaign, a gay rights group, said Collins has "forever changed the face of sports."

"No longer will prejudice and fear force gay athletes to remain silent about a fundamental part of their lives," Griffin said.

The NBA player also received support from Rep. Joe Kennedy III, D-Mass., his college roommate. Kennedy tweeted Monday that "I've always been proud to call (Collins) a friend, and I'm even prouder to stand with him today."

___

AP White House Correspondent Julie Pace contributed to this report.

___

Follow Mary Clare Jalonick on Twitter at http://twitter.com/mcjalonick

Follow Josh Lederman on Twitter at http://twitter.com/joshledermanAP

Source: http://news.yahoo.com/obama-calls-collins-offers-support-coming-223006145.html

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Never Stop Learning About Yourself: Quality Advice For Self ...

Sunday, April 28th, 2013 at 7:22 pm ?

TIP! Avoiding decisions means missing opportunities in the arena of personal development. You should not fear making decisions even if you do not feel as sure about it as you would like to be.

Working on you and your personality is an important thing to do. Self improvement consists of improving your life, whether it?s a healthier financial life or a healthier physical life. You should always be working on yourself. Personal development is a process that never ends, since you always have areas in which you could be better. You can lead a healthy and happy life by establishing and continuing good spending habits.

TIP! Your core principles are important, and your actions should reflect them. All people have beliefs that tell what they are about.

Always be ready to capture your good ideas when they occur, wherever you may be. Take notebook or journal with you, or even make notes on your cellular phone pad. Scribble detailed notes when something comes to you, and then carry them out whenever your creativity is piqued.

TIP! Building a better you starts with building leadership tendencies. When thinking about leadership, think about it in terms of your level of influence on the world around you.

If you take proper care of your physical needs, you will get the maximum benefit from your self improvement approach. A good diet, a lot of sleep and activity will give you more energy and help you get a healthier and better-looking body. Even though it sounds simple enough to do, it could also be one of the toughest things to get into.

Exercising is not only a way to lose weight. There are many physiological benefits associate with exercise. For instance, regular exercise is a great way to boost your mood.

Give others compliments. Instead, show kindness and compassion for others and you will see how much better you will feel about yourself.

TIP! You have to care for yourself before you can start taking care of others. No matter how much progress you have made in your personal development, always make resting and restoring yourself a top priority.

Begin a fund for emergency purposes. Many people handle every unexpected expense with a credit card, building up debt. If you take a few dollars and put them into an emergency fund every week, you will build a nice amount of money to use whenever something unexpected arises. This ?rainy day fund? gives the security of knowing we can manage our expenses and pay off our debts.

TIP! Therapy is a great way for anyone who wishes to work on personal development to explore their own personal demons. Although many can be helped by self help books, often a personal touch or human interaction can be more effective.

Ask other people about their accomplishments instead of bragging about your own. People will appreciate your company more, and you will find new common points of interests between you and your friends.

TIP! Seeing a counselor or therapist can be beneficial. They are trained to help you with issues, and also are experienced.

Be respectful no matter how much, or how little, power the people you talk to wield over you. Treating people badly as a matter of principle reflects a bad personality on your part rather than theirs.

TIP! No matter what another person?s position in life may be, remember to always treat them with respect. Your treatment of others is a direct reflection of you character.

One part of depression you may not thought of to look at is your diet and increasing the amount of complex carbohydrates that you consume. If you are not getting enough complex carbs, you serotonin levels will be low. You can accomplish this by increasing the amounts of raw vegetables and fresh fruits as well as nuts, whole grains, brown rice and assorted beans.

TIP! Perhaps you have set high goals for yourself and keep failing to attain them. If this is the case, it is a good idea to stop and think why.

You only need to remember one key to live and lead a successful life. No matter what other steps you take, the one critical decision you must make is to be active in your life, not a bystander. Watching life go by, without participating, cuts you off from the world, and humans were meant to get out there and live life.

TIP! Becoming healthier will help immensely during personal development. Feeling good is closely associated to good health.

If you?re not living up to the goals that you set for yourself, take a good hard look at what may be wrong. Check online and find others whom share similar goals with you and find out what they are doing compared to what you?re doing. The issues holding you back might include not making enough of an effort, employing a flawed method, or aiming for goals that are too ambitious.

TIP! Figure out what you want your life to be and do what it takes to accomplish it. You won?t get anywhere if you only think about what you want to do.

It may become discouraging to begin developing better personal habits and lifestyles, but once you start noticing your life developing towards a better future, you will never want to stop. You can always develop better ways to do things and it?s important to always try hard towards any personal development goals you have.

p.s. Make sure to share and comment if you found this article useful. Thank you!

p.s.s. Listen to our tracks here.

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Source: http://floatnabove.com/never-stop-learning-about-yourself-quality-advice-for-self-improvement

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Monday, April 29, 2013

An Interview with Filmmaker Nathan Punwar ? The Digital Den

Nathan Punwar is an independent filmmaker based in Brooklyn, NY. He screened his last short film, ?Memory By Design,? at the New York Film Festival and Slamdance Film Festival, among others. In 2012, he edited ?Charlie Is My Darling ? Ireland 1965,? an hour-long documentary on The Rolling Stones constructed entirely from footage shot over one weekend, revealing unseen live performances and backstage antics of the band in their youth. His latest directorial project, a 25-minute narrative short film titled, ?Loves of a Cyclops,? will be playing festivals this year. He collects the current and ongoing projects he makes with friends at the website incompleterecordings.com.

SeagateCreative: Tell us about the inspiration behind the story for your new short film, ?Loves of a Cyclops??

NP: Nathan Punwar: A few years ago, I had an image in my mind of a person with a lens for an eye ? someone who saw the world through a viewfinder instead of his own eye. It was just that image. I thought I might animate it.

Over time, I started to think about what it would mean to require a device to translate the world into something that made sense, and how each animal sees the world differently. Each eye is a different lens, a different interpretation. These thoughts formed a story about a one-eyed man who can?t see the world his peers do, so he struggles to find his place in it.

SC: When you have a new, fresh idea, how do you decide if it?s worth pursuing?

NP: It?s just a matter of how persistent the idea is, how long it can stick in your head and refuse to leave. So you have no choice but to give into the idea until you get it out of your head. For me, getting it out involves walking it down every potential avenue and then backtracking to the one path that seems best to explain it to everyone else.

SC: Do you have a specific technique or ritual you use for creating?

NP: There is no technique other than to try to allow myself to be as perceptive as possible to my surroundings. This includes truly listening to people, which isn?t always as easy as it seems it should be. So there?s that, and the fine balance between it and allowing the mind to wander and float away on a tangent midday.

SC: You wrote, directed, and edited this film. Is there a particular step you find the most creative?

NP: It?s all creative and fulfilling. Writing is the most frustrating and potentially rewarding. If that goes well, and it rarely does, it makes the rest more fruitful, because you?re crafting from material that is already quality. But each part relies so precariously on the others to succeed, which is why I like doing all of it, but definitely not all at once.

SC: In terms of gear and equipment, is there a specific piece that helped you create a breakthrough in filmmaking?

NP: Simply owning a camera that we can use both casually and professionally? Even though we want to spend as much time as possible preparing to make a film as good as it can be, now we can shoot something that strikes us at any moment and repurpose it later, or play with the footage anywhere. At the very least, this means my sketchbook is no longer restricted to the page.

SC: Is there any experience you have from other art forms that play into your ability to make a film?

NP: Though I?m not a true musician, I?ve played music my whole life. I might consume more music than I do films, so a soundtrack is always on my mind. But I try other arts, even ones I?m bad at, because good films involve photography, performance, writing, design, music, fashion, architecture, lighting, and more. If one falters, so does the end result.

A film may not be pure in the same way other arts are, but it has the ability tie them together to convey something in a way that none can on their own, which is why I want to understand and answer to each and every aspect individually.

SC: How did you work on the music for this film, then?

NP: Our composer is Mike Schanzlin, and I would say he and I are on a similar wavelength with music. We make mixes together, and talk about collaborating on ideas often, even though he really knows how to record and play, and I don?t. So he turns my abstract descriptors into musical themes with his studio magic. There was one song I really wanted to include, though, outside of our original score. It?s an early demo recording by Real Estate, and the guys in the band were very cool about letting us use it in the film.

SC: Where there any significant obstacles you encountered while trying to make this film?

NP: Our greatest obstacles were really self-imposed. We decided upon three things from the beginning. The first was that we would primarily cast non-professional actors, mostly friends. The second was that we would make the film with equipment we owned or had access to, with no real budget other than what I could afford to spend out of my own pocket. The third was that we would schedule around everyone?s day jobs. For these reasons and more, it took us about a year to finish a 25-minute film. But these limitations also led us to have some of the most fun and strange experiences on our shoots, the kind you can?t have on a set where significant money is being spent every minute.

SC: What?s one piece of advice you?d give an aspiring filmmaker to help them develop their ideas?

NP: I?m still aspiring, too, so I guess my advice to myself is to take a different route each time. Whoever didn?t get the last thing might get the next thing. Even if I?m still exploring the same ideas that interest me most, at least it?ll be in new and different ways, allowing the work to discover more deeply, or at least find its way to new audiences.

SC: Where is ?Loves of a Cyclops? screening and what?s next from you that we can look forward to?

NP: ?Loves of a Cyclops? will be screening at festivals this year, with additional screenings in New York City. My partner Kathleen Kyllo (who produced and stars in Loves of a Cyclops) and I are attempting our first feature script together, or some kind of series, or whatever it turns into. At some point, we?ll have to figure out a way to finance these things, but for now, we?re just focused on trying to write something true and good.

Source: http://consumer.media.seagate.com/2013/04/the-digital-den/an-interview-with-filmmaker-nathan-punwar/

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Friday, April 26, 2013

NBC plans 'The Million Second Quiz,' a twelve-day, 24 / 7 game show

NBC plans twelve day, 24  7 'The Million Second Quiz' game show for the fall

Second screen experiences connected to TV shows haven't exactly set the world on fire, but NBC will give it another try with a new game show this fall. The Million Second Quiz is being promoted as a non-stop, twelve day trivia game with an "unprecedented level of interactivity" for viewers. In a move that harkens back to our memories of 1 vs 100 on Xbox Live a few years ago, viewers at home can play along and possibly win a spot on the show. While the competition will go on around the clock, the show airs during prime time. It will broadcast live from an "hourglass-shaped structure" located in Manhattan where the four reigning champs will reside as long as they can stay on top throughout the two week competition. Once the million seconds are up, the four champions will face off for a cash prize of up to $10 million. We'll need more details before we can decide if this is more Ultimate Ninja Warrior or Oh Sit! / Splash / Bet On Your Baby (these are all real game shows, we promise), but it's one to keep an eye out for when the all new shows debut.

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Comments

Source: The Million Second Quiz (Facebook), Million Seconds (Twitter)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/bOA1nYv46jI/

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How To Manage Social Media | Content for Reprint

Author: Martie McCabe | Total views: 31 Comments: 0
Word Count: 828 Date:

Website marketing can work wonders for your reputation. It has become essential that you have a successful online promotion strategy in place for your business. Now is the time to get into it. This article will give you help on how you should begin online marketing.

Evaluate your website on a regular basis by asking for constructive feedback. This is very important to your business, as your perception of your prices and your site's appearance might differ from the customer's opinion. Ask peers, family members and your potential clients for feedback. Seek advice and opinions and act on valid opinions and suggestions.

Design an all-inclusive website with an emphasis on fresh, relevant content. Your priority should be to pass as much knowledge as you can to consumers about your products. Don't pad or fluff; stick to stating the essential data that the customer needs to know.

Direct marketing through top social media agencies,can be an effective part of you Website marketing plan. Contact customers by fax, phone, or email and tell them about your specials and services. You may find their contact information in the phone book or online, but it's even better if they have trusted you with their numbers so they will not feel like you are spamming them.

If you want your customers to trust you, back up any claims with actual proof. You can talk a good game about your product, but sharing a video or photo that provides proof that you're selling a solution goes a long way. This illustrates why you need to sell any products you have used if possible.

One important suggestion for marketing on the Internet is to adjust the content, as well as content delivery, to have your customers be under the impression they have complete control. This is an effective marketing strategy. Make it clear from the beginning that participation is voluntary and you will be seen as much more credible.

Making and uploading a viral video and including tags in your video will aid in your internet marketing success. Make sure to link to your site in the video description. This can help boost the number of visitors on your site regularly.

You should include a chat section for customers on your social media website. This will make people feel like they are part of a group, not just a customer. People enjoy being part of groups and clubs so treating them as if they are part of a select group will keep them coming back to your site.

If you issue a news release, it might drum up some internet business. If you have the ability to write press releases which are crisp and have clarity, there are numerous online sources available which will publish and release the material to markets in your niche. You can boost your presence in this way.

Even if you plan to outsource your email marketing, you should know the basic methods behind Internet promotion. You should be able to master the necessary tools in no time. This type of experience will be extremely useful for you throughout the entire life cycle of your products and services.

It is essential that you find the right places to advertise your business online. You can't sell baseball cards to someone that wants to buy old Star Wars toys. People will look for what they need in areas that offer exactly what it is that they are looking for. So, in short, be thoughtful of the places that people interested in your business would be looking online before choosing where to advertise.

Try using words like "simple" and 'easy" in your marketing strategy. People are hesitant to order from sites if the process is too complicated. It is a beneficial way to boost business.

Lure new customers to visit your site by offering them an incentive, such as a free product or service. This makes for savvy Affiliate marketing, because your free product acts as a persuasive advertisement for the materials you're actually trying to sell. You can use your ad campaign to detail your customers about the contest.

Here is a tip for website marketing! Customers should never have to hunt to find what you're selling. This is where you sell the product. The customer should know right away what you're selling on your landing page. If they have to look around on your site for the information they want, they will likely leave more quickly.

Your eyes should be open as to how you can market your business through the internet. There are many different ways you can approach this. You can also learn a lot about how to make this work for your business. By using this advice, you will be successful at Online marketing in no time.

Martie McCabe is an internet marketer.. My articles focuses on developing strategies and tips on how to become a social media specialist. Learn more about promoting your blog with social media articles, by clicking here.

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1: Article Marketing Strategy: Putting Together a "Class Schedule" For Your Article Topics

Businesses go to so much trouble when there is one sure-fire, simple, very inexpensive way to attract new clients to a business: Teach a free class. That is what article marketing is like. Your articles are just like free classes. You teach your target readers something helpful in your article. Your resource box then says, "If you enjoyed this article you can visit my website and apply what you have learned."

2: Why You Need To Build Multiple Streams of Income For Yourself

Being an entrepreneur and earning multiple streams of income is a dream that many have, but in reality it does take some initial hard work to achieve this. Earning multiple streams of income is the wave of the future, and here are some tips and advice for you when you are looking for ways in which to do this for yourself.

3: Understanding Online Business Success

Starting a home based business to earn income online takes a significant amount of time and energy upfront to get things going. Not seeing results immediately can be discouraging and cause people to give up too early. In this article, we look at the process of starting a home based business and working through the frustrations to be there when the sales come flowing in.

4: What is Cyber Marketing And Why It Is So Important For The Success Of Your Website

Cyber marketing has now become an indispensable segment of e-commerce as well as the internet and World Wide Web related topics. Cyber marketing simply refers to a technique of attracting potential customers by advertising your products or services through such means as websites, emails, and banners.

5: The Best Way To Optimise Your Website SEO For Google Panda

If you want your SEO to work you now need to concentrate on appeasing Google Panda, and to do this you need to know what Google Panda's spiders/bots will be looking for. Find out here how to search engine optimise your website for the latest Google Panda algorithm, and achieve the success you deserve.

Source: http://www.content4reprint.com/internet-marketing/how-to-manage-social-media.htm

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Sunday, April 7, 2013

Minnesota Energy Tip: Saving Money

Written by the Minnesota Department of Commerce

April is Financial Literacy Month, a campaign to help focus on our finances and develop healthy financial habits. One of the best ways to save money?month after month?is to conserve energy.

Whether it?s the middle of the hot summer or the dead of winter, there are several basic no- or low-cost measures you can take to conserve energy and decrease your utility bills:

  • Use a programmable thermostat to reduce your heating and cooling costs.
  • Turn off computers and monitors when not in use.
  • Plug home electronics, such as TVs and DVD players, into power strips and turn the strips off when equipment is not in use.
  • Turn off lights when not in use.
  • Close your fireplace damper when not in use.
  • Take short showers; turn your hot water heater down to 120 degrees.
  • Wash only full loads of dishes and clothes; air dry when possible.
  • Replace inefficient incandescent light bulbs with ENERGY STAR? rated compact fluorescent light bulbs (CFLs) or light emitting diodes (LEDs).
  • Look for the ENERGY STAR? label when purchasing new appliances, lighting, and electronics.
  • Have a home energy assessment to identify ways to make your home more energy efficient (weather-strip doors and windows, seal air leaks, add insulation, and more).
  • Go to work via carpool or vanpool, or use public transportation.

For more energy-saving tips, check out the U.S. Department of Energy?s Energy Savers website. Also, the Division of Energy Resources offers an energy guide called ?Appliances, Lighting & Electronics? and a fact sheet called ?Ten Ways to Save Energy? that address ways to save energy.

Source: http://centralmn.wdio.com/news/home-garden/56592-minnesota-energy-tip-saving-money

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What makes subliminal mp3 downloads different from ... - Get self-help

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Source: http://www.selfhelpable.com/subliminal-mp3-downloads/

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Afghan attacks kill U.S. diplomat, soldiers, others

KANDAHAR, Afghanistan (Reuters) - A car bomb blast killed five Americans, including three U.S. soldiers and a young diplomat, on Saturday, while an American civilian died in a separate attack in the east.

The diplomat and other Americans were in a convoy of vehicles in Zabul province when the blast occurred, Secretary of State John Kerry said in a statement.

The soldiers and the diplomat died in the blast along with a civilian employee of the Defense Department and Afghan civilians, Kerry said. His statement gave no overall death toll.

The Washington Post identified the diplomat as Anne Smedinghoff, 25, citing her parents. Smedinghoff was Kerry's embassy guide and aide when he visited Afghanistan last month, the paper said.

Local and international officials in the region said earlier that six people died in the blast: three U.S. soldiers, two U.S. civilians and an Afghan doctor.

Provincial governor Mohammad Ashraf Nasery was in the convoy, but was unharmed, local and NATO officials said.

"Our American officials and their Afghan colleagues were on their way to donate books to students in a school in Qalat, the province's capital, when they were struck by this despicable attack," Kerry said in his statement.

He said he had met the diplomat during a trip to Kabul, and spoke to her parents after her death. Four other U.S. diplomats were wounded, one critically, Kerry said in his statement.

The convoy was near a hospital and a NATO base at the time of the explosion. Five Afghans, including a student and two reporters, were wounded, a local official said.

The attack came as the top U.S. general, Martin Dempsey, chairman of the Joint Chiefs of Staff, arrived in the country for a short visit to assess how much training Afghan troops need before U.S. troops pull out as planned by the end of 2014.

In an attack in Afghanistan's east, an American civilian working with the U.S. government was killed during an insurgent attack, the NATO-led International Security Assistance Force said in a statement.

Zabul shares borders with Pakistan to the southeast and Kandahar province, the birthplace of the Taliban, to the south.

The Taliban claimed responsibility for the Zabul attack in a text message from spokesman Qari Yousuf Ahmadi. He said a car bomb killed seven foreigners and wounded five others, although he later revised the toll to 13 foreigners killed and nine wounded.

The Taliban routinely exaggerates casualty figures.

The killings followed a bloody Taliban assault in the country's west on Wednesday that killed 44 people in a courtroom in Farah province. The United Nations says civilians are being increasingly targeted.

In a statement posted online earlier on Saturday, Ahmadi said the Taliban would continue to target Afghan judges and prosecutors.

"The Islamic Emirate, from today onwards, will keep a close watch over courthouses, all its personnel and all those who try to harm Mujahideen and will deal with them the same as the judges and prosecutors of Farah."

(Reporting by Ismail Sameem, additional reporting by Paul Eckert; Writing by Dylan Welch and Diane Bartz; Editing by Doina Chiacu and Xavier Briand)

Source: http://news.yahoo.com/afghan-attacks-kill-u-diplomat-soldiers-others-021108162.html

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Thursday, April 4, 2013

Of course you'll put up with ads in your Facebook Home

Mark Zuckerberg

It was a simple, direct question asked more than once today at Facebook HQ in Menlo Park in Silicon Valley. There are ads on Facebook. Will there be ads in Facebook Home, the new Android home screen replacement (along with its snazzy if underwhelming new phone) that'll be available starting next week?

Apparently those of us in the audience needed a little clarification, despite the answer having been delivered just minutes before.

"Yup," said Mark Zuckerberg, this time leaving absolutely no doubt.

At some point, Facebook Home will have ads. Not next week, but somewhere down the road.

And you'll be perfectly OK with that. And if you're not, it won't matter.

read more

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/fdBcb-6eaes/story01.htm

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Wild mice have natural protection against Lyme borreliosis

Apr. 4, 2013 ? Like humans, mice can become infected with Borrelia. However, not all mice that come into contact with these bacteria contract the dreaded Lyme disease: Animals with a particular gene variant are immune to the bacteria, as scientists from the universities of Zurich and Lund demonstrate. Wild mice are the primary hosts for Borrelia, which are transmitted by ticks.

Springtime spells tick-time. Lyme borreliosis is the most common tick-borne disease in Switzerland: around 10,000 people a year become infected with the pathogen. The actual hosts for Borrelia, however, are wild mice. Like in humans, the pathogen is also transmitted by ticks in mice. Interestingly, not all mice are equally susceptible to the bacterium and individual animals are immune to the pathogen. Scientists from the universities of Zurich and Lund headed by evolutionary biologist Barbara Tschirren reveal that the difference in vulnerability among the animals is genetic in origin.

Protective gene variant

Tschirren and colleagues examined wild mice for signs of a Borrelia infection in a large-scale field study. Borrelia afzelii -- the scientific name for the bacteria -- feed on mouse blood. The researchers discovered that mice with a particular variant of the antigen receptor TLR2 were around three times less susceptible toBorrelia. "The immune system of mice with this receptor variant recognizes the pathogen better and can trigger an immune response more quickly to destroy the Borrelia in time," says Tschirren. Infected mice exhibit similar symptoms to humans -- especially joint complaints. Consequently, in the wild infected mice probably do not survive for very long and weakened animals soon fall victim to foxes and birds of prey.

Arms race between mice and Borrelia

The protective gene variant is advantageous for its carriers and, according to the researchers, gradually becoming prevalent in the mouse population. Nonetheless, it is unlikely that all mice will one day be resistant to Borrelia. "The increasing resistance in the host is bound to lead to adaptations in Borrelia," predicts Tschirren. "We can observe the evolutionary adaptation through the rearmament in mice and the pathogen."

People also have the antigen receptor TLR2, but not the resistant gene variant observed in mice. Whether the evolutionary arms race between mice and Borrelia will have repercussions for people remains to be seen. According to Tschirren, the bacterium does not necessarily have to become more aggressive for humans.

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The above story is reprinted from materials provided by University of Zurich.

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Journal Reference:

  1. B. Tschirren, M. Andersson, K. Scherman, H. Westerdahl, P. R. E. Mittl, L. Raberg. Polymorphisms at the innate immune receptor TLR2 are associated with Borrelia infection in a wild rodent population. Proceedings of the Royal Society B: Biological Sciences, 2013; 280 (1759): 20130364 DOI: 10.1098/rspb.2013.0364

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/c_6W7tVBk_o/130404072925.htm

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North Carolina?s Turn On The Rack, Again (Balloon Juice)

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Wednesday, April 3, 2013

How antibodies neutralize mosquito-borne virus

Apr. 2, 2013 ? Researchers have learned the precise structure of the mosquito-transmitted chikungunya virus pathogen while it is bound to antibodies, showing how the infection is likely neutralized.

The findings could help researchers develop effective vaccines against the infection, which causes symptoms similar to dengue fever, followed by a prolonged disease that affects the joints and causes severe arthritis. In recent outbreaks, some cases progressed to fatal encephalitis.

The researchers studied "virus-like particles," or non-infectious forms of the virus. They also obtained near atomic-scale resolution of the virus attached to four separate antibodies.

"We knew these antibodies neutralize the real virus, so we wanted to know how they do it," said Michael Rossmann, Purdue University's Hanley Distinguished Professor of Biological Sciences.

Findings are detailed in a research paper appearing Tuesday (April 2) in the journal eLife.

The scientists used a technique called cryoelectron microscopy to uncover critical structural details about the virus-like particles bound to the antibodies. The particles are made of 180 "heterodimers," molecules made of two proteins: envelope protein 1, or E1, and envelope protein 2, or E2.

The findings show the precise structure of the virus-like particle bound to a key part of the antibodies, called the antigen binding fragment, or Fab, which attaches to the heterodimers making up the virus's outer shell. The analyses showed that the antibodies stabilize the viral surface, hindering fusion to the host cell and likely neutralizing infection.

Chikungunya is an alphavirus, a family of viruses that includes eastern equine encephalitis.

"This is the first time the structure of an alphavirus has been examined in this detail," Rossmann said.

The research is aimed at learning precisely how viruses infect humans and other hosts, knowledge that may lead to better vaccines and antiviral drugs, Rossmann said.

Chikungunya in 2005 caused an epidemic on R?union Island. A mutation in the E1 protein has allowed the virus to replicate more efficiently, which is considered the primary reason for its recent extensive spread, infecting millions of people in Africa and Asia.?

The research team conducted experiments to record the structure of the virus in different orientations and obtained a three-dimensional structure with a resolution of 5.3 ?ngstroms, or 5.3 ten-billionths of a meter.

The research, funded by the NIH, is ongoing and involves one graduate student and five postdoctoral students. One goal is to learn how the virus is modified when the antibodies bind to the virus and to obtain higher-resolution images.

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The above story is reprinted from materials provided by Purdue University. The original article was written by Emil Venere.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. Sun, Y. Xiang, W. Akahata, H. Holdaway, P. Pal, X. Zhang, M. S. Diamond, G. J. Nabel, M. G. Rossmann. Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization. eLife, 2013; 2 (0): e00435 DOI: 10.7554/eLife.00435

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Cfy9Tl7N-yY/130402125044.htm

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Private sector hiring pace slows, survey says

Private employers added 158,000 jobs in March, the smallest gain in five months and falling short of economists' expectations, a report by a payrolls processor showed on Wednesday.

Economists surveyed by Reuters had forecast the ADP National Employment Report would show a gain of 200,000 jobs. The report came in below the lowest estimates in a poll by Reuters and was the smallest gain since October.

Revisions to February's jobs gains were more positive, with the private payrolls figure raised to an increase of 237,000 from the previously reported 198,000, though January was revised down to 177,000 from 215,000.

The euro extended gains against the dollar immediately following the report, while Treasury bonds turned higher. U.S. stock index futures saw little reaction around flat levels.

The ADP report, which is jointly developed with Moody's Analytics, comes ahead of the government's more comprehensive labor market report on Friday.

That report includes both public and private sector employment and is expected to show a gain in overall nonfarm payrolls of 200,000 last month, while the unemployment rate is seen holding steady at 7.7 percent.

"It tilts the risk in that (weaker) direction for Friday's payroll numbers," Jim O'Sullivan, chief U.S. economist at High Frequency Economics in Valhalla, New York, said of the ADP report.

"It doesn't mean the trend of job growth has suddenly slowed, but that's what people are worried about."

Economists often refer to the ADP report to fine-tune their expectations for the payrolls numbers, though it is not always accurate in predicting the outcome.

Copyright 2013 Thomson Reuters.

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Diversification in ancient tadpole shrimps challenges the term 'living fossil'

Apr. 2, 2013 ? The term 'living fossil' has a controversial history. For decades, scientists have argued about its usefulness as it appears to suggest that some organisms have stopped evolving. New research has now investigated the origin of tadpole shrimps, a group commonly regarded as 'living fossils' which includes the familiar Triops. The research reveals that living species of tadpole shrimp are much younger than the fossils they so much resemble, calling into question the term 'living fossil'.

Darwin informally introduced the term 'living fossil' in On the Origin of Species when talking about the platypus and lungfish, groups that appear to have diversified little and appear not to have changed over millions of years. For him living fossils were odd remnants of formerly more diverse groups, and suggestive of a connection between different extant groups. Ever since, the term has been widely used to describe organisms such as the coelacanth, the horseshoe crab and the ginkgo tree. The term has been controversial, as it appears to suggest that evolution has stopped altogether for these organisms, and some scientists have argued that it should be abandoned.

Tadpole shrimps are a small group of ancient crustaceans (a group which includes the familiar Triops) that are often called 'living fossils', because the living species look virtually identical to fossils older than the dinosaurs. Analysing DNA sequences of all known tadpole shrimps, and using fossils from related crustacean groups -- such as the water flea and the brine shrimp -- the team of researchers, from the University of Hull, University of Leicester and the Natural History Museum in London, showed that tadpole shrimps have in fact undergone several periods of radiation and extinction. The new study is published today in PeerJ, a new peer reviewed open access journal in which all articles are freely available to everyone (https://PeerJ.com).

Different species of tadpole shrimp often look very similar (they are called 'cryptic species'), and so it is only with the advent of DNA sequencing that scientists have realized that they are a surprisingly diverse group. The team's results uncovered a total of 38 species, many of them still undescribed. This abundance of 'cryptic species' makes it very difficult for fossils to be assigned to any particular species as they all look remarkably similar. For example, 250-million-year-old fossils have been assigned to the living European species Triops cancriformis whereas the team's results indicate that the living T. cancriformis evolved less than 25 million years ago. First author Tom Mathers says "In groups like tadpole shrimps where cryptic speciation is common, the fossil record says very little about patterns of evolution and diversification and so the term 'living fossil' can be quite misleading. For this reason, we used fossils from related groups to gain an understanding about the evolution of tadpole shrimps."

The lead author Africa G?mez said, "Living fossils evolve like any other organism, they just happen to have a good body plan that has survived the test of time. A good analogy could be made with cars. For example the Mini has an old design that is still selling, but newly made Minis have electronic windows, GPS and airbags: in that sense, they are still 'evolving', they are not unchanged but most of the change has been 'under the hood' rather than external. By comparison, organisms labeled as 'living fossils' such as tadpole shrimps, are constantly fine-tuning their adaptation to their environment. Although outwardly they look very similar to tadpole shrimp fossils from the age of the dinosaurs, their DNA and reproductive strategies are relatively hidden features that are constantly evolving. The flexibility of their reproductive strategies, which our research has revealed, could be the evolutionary trick that has allowed them to persist as a morphologically conservative group for so long."

Background

Tadpole shrimps include the familiar Triops -- which is often sold as dried eggs in toy shops -- that can easily be grown at home. Their fossils can be found from the Carboniferous, 300 million years ago, and the group has survived several mass extinction events. Currently, tadpole shrimps occupy a range of temporal aquatic habitats with different water chemistry conditions, such as hypersaline Australian lakes, rice fields, coastal pools, river floodplains and arctic ponds. Their eggs can survive in a dry state for several decades, only hatching when suitable conditions return.

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The above story is reprinted from materials provided by PeerJ.

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Journal Reference:

  1. Thomas C. Mathers, Robert L. Hammond, Ronald A. Jenner, Bernd H?nfling, Africa G?mez. Multiple global radiations in tadpole shrimps challenge the concept of ?living fossils?. PeerJ, 2013; 1: e62 DOI: 10.7717/peerj.62

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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/E7oZsAI-y4Q/130402091641.htm

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